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Etoposide (VP-16)-induced Apoptosis in Human Non-small Cell Lung Cancer Cells Lacking Endogenous

By 邱建智

Abstract

[[abstract]]VP-16 (etoposide), an inhibitor of topoisomerase IIα, was widely used for cancer therapy. We found low dosage of VP-16 causes apoptosis in cancer cells without functional p53. In this work, we have identified that caspases were responsible for the progression of apoptosis in VP-16-induced H1299 cells lacking endogenous p53. Further study showed that apoptosis effectors caspase-9 and caspase-7 were activated prior to apoptosis. This work also demonstrated that VP-16-induced apoptosis in human non-small cell lung cancer cells is independent of p53 status.

Topics: 細胞凋亡 ; 人類非小細胞肺癌, VP-16 ; Etoposide ; Caspase-7 ; Caspase-9 ; Human non-small cell lung cancer ; Apoptosis
Publisher: 國立臺灣師範大學生命科學學系
Year: 2010
OAI identifier: oai:ir.lib.ntnu.edu.tw:309250000Q/7861
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