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Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

By Anna Tchenio, Salvatore Lecca, Kristina Valentinova and Manuel Mameli

Abstract

International audienceEarly-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABA B-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability—an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors

Topics: [SDV]Life Sciences [q-bio]
Publisher: 'Springer Science and Business Media LLC'
Year: 2017
DOI identifier: 10.1038/s41467-017-01192-1
OAI identifier: oai:HAL:hal-01633963v1
Provided by: HAL-Inserm
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