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The Effectiveness of Phalleria Macrocarpa Bioactive Fraction in Alleviating Endometriosis And/or Adenomyosis Related Pain

By B. (Budi) Wiweko, C. G. (Caroline) Puspita, R. (Raymond) Tjandrawinata, H. (Herbert) Situmorang, A. K. (Achmad) Harzif, G. (Gita) Pratama, K. (Kanadi) Sumapraja, M. (Muharam) Natadisastra and A. (Andon) Hestiantoro

Abstract

The overexpression of estrogen receptor-beta (ER-ß) and the cyclooxygenase-2 (COX-2) enzyme coupled with the absence of expression of progesterone receptors (PR) is critical to thepathogenesis of endometriosis and adenomyosis associated pain.  DLBS1442, a novel bioactiveextract of Phaleria macrocarpa, exerts its action by downregulating the overexpressed ER-ß andCOX-2 products and up-regulating PR gene expression. This pilot study was conducted to evaluatethe effectiveness of DLBS1442 treatment in alleviating endometriosis- and/or adenomyosis-relatedpain. Ten endometriosis and/or adenomyosis patients were recruited consecutively at YasminClinic Dr. Cipto Mangunkusumo General Hospital in January - March 2013. Pain associated withmenses, including pre-menstrual pain, dysmenorrhea, dyschezia and dysuria, was measuredusing the visual analog scale (VAS) at each of the next three menstrual cycles. Patients reportingone or more pain symptoms with a VAS score = 4 were given 100 mg of DLBS1442 three timesdaily for 12 weeks. VAS score reduction was noted in the first post-treatment menstrual cycle(approximately 5.3 weeks after treatment initiation) and VAS scores continued to decline overthe final two cycles. DLBS1442 was effective in alleviating endometriosis- and/ or adenomyosisrelatedpain, as demonstrated by early pain reduction as evaluated using the VAS

Topics: Indonesia, adenomiosis, dismenorea, DLBS 1442, endometriosis, dysmenorrhea, DLBS1442, DLBS1442, dysmenorrhea, endometriosis, DLBS 1442, dismenorea, adenomiosis
Publisher: 'Universitas Islam Indonesia (Islamic University of Indonesia)'
Year: 2015
DOI identifier: 10.23886/ejki.3.4824.
OAI identifier: oai:neliti.com:60762
Provided by: Neliti

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