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Assessing evidence for avian-to-human transmission of influenza A/H9N2 virus in rural farming communities in northern Vietnam

By L.N.M. Hoa, N.A. Tuan, P.H. My, T.T.K. Huong, N.T.Y. Chi, T.T. Hau Thu, J. Carrique-Mas, M.T. Duong, N.D. Tho, N.D. Hoang, T.L. Thanh, N.T. Diep, N.V. Duong, T.K. Toan, T.S. Tung, L.Q. Mai, M. Iqbal, H.F.L. Wertheim, H.R. van Doorn, J.E. Bryant and C. The Vizions

Abstract

Item does not contain fulltextRural farming communities in northern Vietnam do not routinely practice vaccination for influenza A viruses (IAV) for either humans or poultry, which enables us to study transmission intensity via seroepidemiology. Using samples from a longitudinal cohort of farming households, we determined the number of symptomatic and asymptomatic human infections for seasonal IAV and avian A/H9 over 2 years. As expected, we detected virologically confirmed acute cases of seasonal IAV in humans, as well as large numbers of subclinical seroconversions to A/H1pdm [55/265 (21 %)], A/H3 [95/265 (36 %)] and A/H9 [24/265 (9 %)]. Five of the A/H9 human seroconverters likely represented true infections rather than heterosubtypic immunity, because the individuals seroconverted solely to A/H9. Among co-located poultry, we found significantly higher seroprevalance for A/H5 compared to A/H9 in both chickens and ducks [for northern study sites overall, 337/1105 (30.5 %) seropositive for A/H5 and 123/1105 (11.1 %) seropositive for A/H9]

Topics: Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences
Publisher: 'Microbiology Society'
Year: 2017
DOI identifier: 10.1099/jgv.0.000877
OAI identifier: oai:repository.ubn.ru.nl:2066/177503
Provided by: Radboud Repository
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