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O-GlcNAc Peptide Epoxyketones Are Recognized by Mammalian Proteasomes

By Martin D. Witte, Bogdan I. Florea, Martijn Verdoes, Oloruntosin Adeyanju, Gijs A. van der Marel and Herman S. Overkleeft


Cytosolic and nuclear proteins may be subject to both O-GlcNAcylation and proteasomal degradation. By means of activity-based profiling, we demonstrate that O-GlcNAc serine-containing peptide epoxyketones bind to the proteasome catalytic active sites and thus provide the first clear evidence that proteasomes recognize peptides post-translationally modified with a GlcNAc moiety.

Year: 2009
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