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Human induced pluripotent stem cell based cell assays; an improvement in disease modeling and toxicity testing?

By A.W.G. Berendsen

Abstract

Human induced Pluripotent Stem Cell (hiPSC) based cell assays are a new promising technology which can help unravel complex interactions and by this cutting in the time and money spend on disease modeling and toxicity testing. HiPSC are somatic cells converted to pluripotent stem cells through expression of a small combination of transcription factors raising the possibility of producing custom-tailored cells for the study of numerous diseases. Indeed, hiPSCs have already been derived from patients suffering from a large variety of disorders indicating the potential of hiPSC. HiPSC possess as the name implies the possibility to differentiate into all cell types of the human body. In this review we will discuss the advantages and limitations of hiPSC based cell assays and the advantages and limitations of the current methods of disease modeling and toxicity testing by research animals and immortalized cell based assays. After that the conclusion about the use of hiPSC based cell assays in disease modeling and toxicity testing is given.

Year: 2011
OAI identifier: oai:ub.rug.nl:dbi/4e8ef61985697
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