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Biomimetic Mussel Adhesive Inspired Clickable Anchors Applied to the Functionalization of Fe3O4 Nanoparticles

By Anja S. Goldmann, Christine Schödel, Andreas Walther, Jiayin Yuan, Katja Loos and Axel H.E. Müller

Abstract

The functionalization of magnetite (Fe3O4) nanoparticles with dopamine-derived clickable biomimetic anchors is reported. Herein, an alkyne-modified catechol-derivative is employed as the anchor, as i) the catechol-functional anchor groups possess irreversible covalent binding affinity to Fe3O4 nanoparticles, and ii) the alkyne terminus enables further functionalization of the nanoparticles by the grafting-onto approach with various possibilities offered by ‘click’ chemistry. In the present work, azido-end group functionalized Rhodamine and poly(ethylene glycol) (PEG) are utilized to coat the iron oxide nanoparticles to make them fluorescent and water soluble.

Year: 2010
OAI identifier: oai:ub.rug.nl:dbi/4d0b87549f57b
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