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Asymmetric Hydrogenation of Quinoxalines Catalyzed by Iridium/PipPhos

By Nataša Mršić, Johannes G. de Vries, Ben L. Feringa, Adriaan J. Minnaard and Thomas Jerphagnon


A catalyst made in situ from the (cyclooctadiene)iridium chloride dimer, [Ir(COD)Cl]2, and the monodentate phosphoramidite ligand (S)-PipPhos was used in the enantioselective hydrogenation of 2- and 2,6-substituted quinoxalines. In the presence of piperidine hydrochloride as additive full conversions and enantioselectivities of up to 96% are obtained.

Year: 2009
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