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Thiophene analogues of phenotiazine neuroleptics. Physicochemical and biological properties of thienobenzothiazines

By Harm Rollema

Abstract

From the investigations described in this thesis the thenobenzothiazines were found to be a useful tool to study the influence of certain properties on neurolpetic activity of compounds which are comparable in parameters affecting the accessibility to a site of action. In this respect it must be realized that this report is an account of ongoing studies, obviously not permitting definite conclusions. The results show that the [3,4-b] thienobenzothiazines with corresponding phenothiazines, and the isomeric [2,3-b]- and [3,2-b] thienzobenzothiazines are two sets of such drugs. Further study of these compounds might contribute tot te elucidation of the mode of action of phenotiazine neuroleptics. ... Summary and conclusions

Year: 1976
OAI identifier: oai:ub.rug.nl:dbi/48119b08c400e
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