The airways are innervated by efferent (motor) as well as afferent (sensory) autonomic nerves, and this autonomic nervous system controls many aspects of airway function. In addition to cholinergic and adrenergic innervation, nonadrenergic noncholinergic (NANC) innervation of the airways is importantly involved in the regulation of many processes in the airways which may influence airway function, such as modulation of airway smooth muscle tone, mucus secretion from submucosal glands, transport of fluid across the airway epithelium, permeability and blood flow in the bronchial circulation, and the release of mediators from mast cells and other inflammatory cells. Thus far, little is known about the role of (neural or non-neural) NO, VIP and endogenous tachykinins in allergen-induced early and late asthmatic reactions, airway hyperreactivity and airway inflammation. The aim of the experiments described in this thesis was to investigate the role of eNANC and iNANC neurotransmission, and non-neural NO in allergic asthma, using a guinea pig model of allergic asthma, which has recently been developed in our department (1,2). ... Zie: Summary
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