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Cyclization in concert

By Marco W. Fraaije and Andrea Mattevi


The berberine bridge enzyme catalyzes the crucial step in the biosynthesis of an important class of alkaloids through a reaction that cannot be carried out using conventional organic chemistry tools. Characterization of the enzyme demonstrates a concerted mechanism that couples two distinct chemical steps—oxidation and proton abstraction—affecting two separate groups of the substrate.

Year: 2008
OAI identifier: oai:ub.rug.nl:dbi/4a1fd556bf6c9
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