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Why is saline so acidic (and does it really matter?)

By B. Reddi


Commercial 0.9% saline solution for infusion has a pH around 5.5. There are many reasons for this acidity, some of them still obscure. It is also true that infusion of normal saline can lead to met-abolic acidaemia, yet the link between the acidity of saline solution and the acidaemia it can en-gender is not straightforward. This commentary draws together the known and putative sources of acidity in saline solutions: it turns out that the acidity of saline solution is essentially unrelated to the acidaemia complicating saline infusion.Benjamin AJ Redd

Topics: saline; acidaemia; titratable acidity; crystalloid; balanced solution; Grotthuss.
Publisher: Ivyspring International Publisher
Year: 2013
DOI identifier: 10.7150/ijms.5868
OAI identifier:

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