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Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)

By Roberta T. dos Santos, Liliane L. Hiramoto, João Henrique G. Lago, Patrícia Sartorelli, André G. Tempone and Erika G. Pinto

Abstract

MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature

Topics: Plectranthus barbatus, 1,2,3,4,6-penta-O-galloyl-β-D-glucose, anti-trypanosomal activity, Chemistry, QD1-999, Science, Q
Publisher: Sociedade Brasileira de Química
Year: 2012
DOI identifier: 10.1590/S0100-40422012001100025
OAI identifier: oai:doaj.org/article:205ea66551b245ce98d47acff3d8b735
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