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Amelioration of intestinal dysmotility and stasis by octreotide early after small-bowel autotransplantation in dogs

By K Nakada, A Ikoma, T Suzuki, JC Reynolds, WL Campbell, S Todo and TE Starzl


Intestinal dysmotility and stasis after intestinal transplantation are considered to promote bacterial overgrowth and translocation. Two prokinetic agents, KW5139 (13-leu-motilin) and the somatostatin analogue octreotide acetate, were studied to determine whether they can ameliorate intestinal dysmotility during the early postoperative period. Motility was recorded by multiple extraluminal strain-gauge transducers in 6 dogs on postoperative days 1, 3, 7, and 14. A barium meal study was performed with a separate group of 8 dogs on postoperative days 3 and 7. The agent KW5139 induced brief, weak contractions in the graft and had little effect on the dilated bowel; however, octreotide induced motor activity that propelled accumulated intestinal contents into the colon and reduced dilation of the transplanted bowel. Octreotide, but not KW5139, ameliorates intestinal dysmotility associated with bowel autotransplantation during the early postoperative period. Short-term administration of octreotide may be useful for the treatment of dysmotility following intestinal transplantation. © 1995, All rights reserved

Year: 1995
DOI identifier: 10.1016/S0002-9610(99)80161-5
OAI identifier:
Provided by: D-Scholarship@Pitt

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