Cyclosporin A and steroid was compared to Imuran and prednisone in a prospective, randomized study of patients undergoing primary cadaver renal transplantation. Graft survival was superior in the cyclosporin-A-treated group, with 1-year kidney function of 92% and less infections. No kidneys were lost to rejection in this group. Further experience with a variety of high-risk patients have reinforced this early experience, showing few kidneys lost to rejection and low incidence of infectious complications using cyclosporin-A and low dose steroid combination
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