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CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

By TE Starzl, I Penn, G Schroter, CW Putnam, CG Halgrimson, G Martineau, H Amemiya and CG Groth

Abstract

Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided. © 1971

Year: 1971
DOI identifier: 10.1016/S0140-6736(71)92046-0
OAI identifier: oai:d-scholarship.pitt.edu:3643
Provided by: D-Scholarship@Pitt

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