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Avaliação de métodos de extração para a determinação de cromo e níquel em formulações farmacêuticas e em matérias-primas usadas na fabricação de medicamentos à base de cefalexina e ciprofloxacino

By Carlos Eduardo R. de Paula, Daniel M. Brum, Luiz Fernando S. Caldas and Ricardo J. Cassella


This paper reports the evaluation of extraction strategies for the treatment of medicine samples to determine chromium and nickel by GFAAS. Different approaches for extraction were evaluated and the most efficient involved magnetic stirring. The metals were quantitatively extracted by stirring 0.20 g samples with 25 mL of 2.0 mol L-1 HCl solution for 60 min. The developed method was successfully applied for the determination of Cr and Ni in tablets containing antibiotics and raw materials, with cephalexin and ciprofloxacin as active ingredients

Topics: extraction procedures, medicines, graphite furnace atomic absorption spectrometry, Chemistry, QD1-999, Science, Q
Publisher: Sociedade Brasileira de Química
Year: 2012
DOI identifier: 10.1590/S0100-40422012000900027
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