Skip to main content
Article thumbnail
Location of Repository

Cell migration in the postnatal subventricular zone

By Menezes J.R.L., Marins M., Alves J.A.J., Fróes M.M. and Hedin-Pereira C.

Abstract

New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in many ways opposite to the classical radial migration of immature neurons: it is faster, spans a longer distance, does not require radial glial guidance, and is not limited to postmitotic neurons. In recent years many molecules have been found to be expressed specifically in this pathway and to directly affect this migration. Soluble factors with inhibitory, attractive and inductive roles in migration have been described, as well as molecules mediating cell-to-cell and cell-substrate interactions. However, it is still unclear how the various molecules and cells interact to account for the special migratory behavior in the RMS. Here we will propose some candidate mechanisms for roles in initiating and stopping SVZ/RMS migration

Topics: Postnatal neurogenesis, Chain migration, Rostral migratory stream, Astrocytes, Gap junctions, Radial glia, Biology (General), QH301-705.5, Science, Q, DOAJ:Biology, DOAJ:Biology and Life Sciences, Medicine (General), R5-920, Medicine, R, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Associação Brasileira de Divulgação Científica
Year: 2002
OAI identifier: oai:doaj.org/article:80fe05d827d047de94193f79ac438c9d
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/0034-7310 (external link)
  • https://doaj.org/toc/0100-879X (external link)
  • http://www.scielo.br/scielo.ph... (external link)
  • https://doaj.org/article/80fe0... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.