This study was conducted to evaluate performance and body composition of tilapia (Oreochromis niloticus) fed diets containing byproducts aerial parts of cassava meal (Manihot esculenta), mesquite pod meal (Prosopis juliflora), cocoa meal (Theobroma cacao) and palm kernel cake (Elaeis guineensis) and to analyze the economic viability of the feed. A total of 1,350 juvenile males (100 g) were distributed in 15 cages (1 m³) in completely randomized design with five treatments (basal diet and four test diets) and three replicates. The following aspects were evaluated: final weight, total feed intake, total weight gain, feed conversion, specific growth rate, protein efficiency ratio and survival rate, dry matter, crude protein, fat and ash body, the average cost of feed per kilogram of weight gain and economic efficiency rate. No differences were observed for total consumption of food or survival rate. For other variables, the inclusion of cocoa and cassava meal impaired fish performance. No differences were observed for dry matter, crude protein and body ash. The lower body fat accumulation was recorded for the tilapia fed palm kernel cake. The best economic indicators were found to diets containing palm kernel cake. The byproducts evaluated can be used up to 150 g/kg in feed formulation, providing good performance and economic rate for Nile tilapia
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