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Tuberculose esplênica durante tratamento de psoríase com infliximabe Splenic tuberculosis during psoriasis treatment with infliximab

By Gleyce Tavares de Melo Fortaleza, Maria de Fátima de Medeiros Brito, Josemir Belo dos Santos, Ana Roberta Figueiredo and Perla Gomes

Abstract

A psoríase é doença crônica que afeta a pele e, eventualmente, as articulações. A terapia biológica age bloqueando citocinas inflamatórias implicadas na patogênese da doença, dentre elas o fator de necrose tumoral alfa. Este também tem papel na defesa do hospedeiro contra o Mycobacterium tuberculosis. Relata-se um caso de psoríase com boa resposta ao infliximabe, porém com desenvolvimento de tuberculose esplênica durante o tratamento.<br>Psoriasis is a chronic inflammatory disease affecting the skin and occasionally the joints. The biological agents have been engineered to target a specific step in the inflammatory cascade that leads to psoriasis, including tumor necrosis factor, which has a central role in the host defense against Mycobacterium tuberculosis. This is a case report about a psoriatic patient who presented splenic tuberculosis during treatment with infliximab

Topics: Psoríase, Terapia biológica, Tuberculose, Psoriasis, Biological therapy, Tuberculosis, Dermatology, RL1-803, Medicine, R, DOAJ:Dermatology, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Sociedade Brasileira de Dermatologia
Year: 2009
DOI identifier: 10.1590/S0365-05962009000400016
OAI identifier: oai:doaj.org/article:8d06f3c7893449459628850ea932a8bf
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