Skip to main content
Article thumbnail
Location of Repository

Improvement of fluconazole flowability and its effect on dissolution from tablets and capsules

By Vladi Olga Consiglieri, Samanta Mourão, Mauricio Sampaio, Patricia Granizo, Pedro Garcia, Valeska Martinello, Rodrigo Spricigo and Humberto Gomes Ferraz

Abstract

The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone® K29/32 or K90. Flow properties of granules and dissolution profiles for tablets and capsules produced with them were determined. Fluconazole granules demonstrated better flowability, calculated by angle of repose and compressibility index data, compared with powder. Additionally, it was observed that the granulation process improved the dissolution efficiency (ED) of fluconazole from tablets and capsules, which could also suggest an increase in bioavailability. Higher dissolution efficiencies were achieved with Plasdone® K29/32.<br>O objetivo deste trabalho foi melhorar as características de fluxo do fluconazol com o emprego da granulação úmida e estudar o efeito desse processo na dissolução do fármaco em cápsulas e comprimidos. O fluconazol foi submetido ao processo de granulação úmida num granulador de alta velocidade empregando Plasdone K29/32 e K90. Foram determinadas as propriedades de fluxo dos grânulos e obtidos os perfis de dissolução de cápsulas e comprimidos obtidos com os granulados em estudo. Os grânulos de fluconazol apresentaram melhores características de fluxo após o processamento, demonstradas por meio das determinações do ângulo de repouso e do índice de compressibilidade, comparativamente à matéria-prima. Adicionalmente, observou-se que o processo de granulação melhorou a eficiência de dissolução (ED) do fluconazol nos comprimidos e cápsulas

Topics: Fluconazol, Comprimidos, Cápsulas, Plasdone, Fluconazole, Tablets, Capsules, Plasdone, Pharmacy and materia medica, RS1-441, Medicine, R, DOAJ:Pharmacy and materia medica, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Universidade de São Paulo
Year: 2010
DOI identifier: 10.1590/S1984-82502010000100013
OAI identifier: oai:doaj.org/article:8ddc2499f5624bfd9eb8e8337aa6812c
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2175-9790 (external link)
  • https://doaj.org/toc/1984-8250 (external link)
  • http://www.scielo.br/scielo.ph... (external link)
  • https://doaj.org/article/8ddc2... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.