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Effect of tomato consumption on high-density lipoprotein cholesterol level: a randomized, single-blinded, controlled clinical trial

By Cuevas-Ramos D, Almeda-Vald&amp, Ch&amp, Meza-Arana CE, Brito-C&amp, Mehta R, P&amp and G&amp

Abstract

Daniel Cuevas-Ramos,1 Paloma Almeda-Vald&eacute;s,1 Emma Ch&aacute;vez-Manzanera,1 Clara Elena Meza-Arana,2 Griselda Brito-C&oacute;rdova,1 Roopa Mehta,1 Oscar P&eacute;rez-M&eacute;ndez,3 Francisco J G&oacute;mez-P&eacute;rez1 1Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias M&eacute;dicas y Nutrici&oacute;n Salvador Zubir&aacute;n, Mexico City, Mexico; 2Department of Internal Medicine, Instituto Nacional de Ciencias M&eacute;dicas y Nutrici&oacute;n Salvador Zubir&aacute;n, Mexico City, Mexico; 3Department of Molecular Biology, Instituto Nacional de Cardiolog&iacute;a Ignacio Ch&aacute;vez, Mexico City, Mexico Introduction: Epidemiologic evidence suggests that tomato-based products could reduce the risk of cardiovascular diseases. One of the main cardiovascular risk factors is low levels of high-density lipoprotein cholesterol (HDL-C). This study aimed to prospectively evaluate the effect of tomato consumption on HDL-C levels. Subject and methods: We conducted a randomized, single-blinded, controlled clinical trial. We screened 432 subjects with a complete lipid profile. Those individuals with low HDL-C (men <40 mg/dL and women <50 mg/dL) but normal triglyceride levels (<150 mg/dL) were included. Selected participants completed a 2-week run-in period on an isocaloric diet and then were randomized to receive 300 g of cucumber (control group) or two uncooked Roma tomatoes a day for 4 weeks. Results: A total of 50 individuals (women = 41; 82%) with a mean age of 42 &plusmn; 15.5 years and a mean body mass index of 27.6 &plusmn; 5.0 kg/m2 completed the study. A significant increase in HDL-C levels was observed in the tomato group (from 36.5 &plusmn; 7.5 mg/dL to 41.6 &plusmn; 6.9 mg/dL, P < 0.0001 versus the control group). After stratification by gender, the difference in HDL-C levels was only significant in women. The mean HDL-C increase was 5.0 &plusmn; 2.8 mg/dL (range 1&ndash;12 mg/dL). Twenty patients (40%) finished the study with levels >40 mg/dL. A linear regression model that adjusted for those parameters that impact HDL-C levels (age, gender, waist-to-hip ratio, body mass index, fasting triglyceride concentration, simple sugars, alcohol, physical activity, and omega-3 consumption) showed an independent association between tomato consumption and the increase in HDL-C (r2 = 0.69; P > 0.0001). Conclusion: Raw tomato consumption produced a favorable effect on HDL-C levels in overweight women. Keywords: lycopene, hypoalphalipoproteinemia, dyslipidemia, overweight, cardiovascular disease

Topics: Medicine (General), R5-920, Medicine, R, DOAJ:Medicine (General), DOAJ:Health Sciences, Specialties of internal medicine, RC581-951
Publisher: Dove Medical Press
Year: 2013
OAI identifier: oai:doaj.org/article:0fdb9d05ac03464da7ca9d8c09f26888
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