Skip to main content
Article thumbnail
Location of Repository

Heparanase Expression Correlates with Angiogenesis and Lymphangiogenesis in Human Lung Cancer

By Qingfu ZHANG, Jian MING, Yang LI, Siyang ZHANG, Bo LI, Xueshan QIU and Enhua WANG

Abstract

Background and objective Heparanase has been thought to be a good molecular marker of tumor, and the heparanase expression level was correlated closely with tumor metastasis. In this study, we investigate the effects of heparanase on angiogenesis and lymphangiogenesis of lung cancer and the relationship between heparanase expression and vascular endothelial growth factor (VEGF), vascular endothelial growth factor-C (VEGF-C). Methods Immunohistochemistry was used to detect the expression of heparanase, VEGF, VEGF-C protein and microvascular density (MVD), lymphatic vessel density (LVD) in 115 cases of non-small cell lung cancer (NSCLC) and 45 cases of adjacent normal tissue samples. Results Our results showed that heparanase expression was significantly increased in 91 (79.13%) of the 115 cases and correlated with lymph node metastasis (node positive rate 87.0%; node negative rate 36.8%; P=0.003). Heparanase positive expression cases have significantly higher concentration of microvascular density (MVD) and lymphatic vessel density (LVD) as compared with heparanase negative expression cases (P<0.01, P<0.01, respectively), heparanase expression was significantly correlated with VEGF, VEGF-C expression in NSCLC. Conclusion Heparanase overexpression was associated with angiogenesis and lymphangiogenesis of lung cancer, targeting of heparanase may represent a significant therapeutic potential for lung cancer

Topics: Lung Neoplasms, Heparanase, Vascular Endothelial Growth Factor-C, Lymphatic Metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Internal medicine, RC31-1245, Medicine, R, DOAJ:Oncology, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Chinese Anti-Cancer Association; Chinese Antituberculosis Association
Year: 2009
OAI identifier: oai:doaj.org/article:205e8fc99de444578baef81e5655179a
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1999-6187 (external link)
  • https://doaj.org/toc/1009-3419 (external link)
  • http://www.lungca.org/index.ph... (external link)
  • https://doaj.org/article/205e8... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.