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Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats

By Ghulam Moinuddin, Kshama Devi and Deepak Kumar Khajuria


Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS).Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST).Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Conclusion: Our study demonstrated the potential antidepressant activity of MS

Topics: Antidepressant activity, Imipramine, Myristica fragrans, Therapeutics. Pharmacology, RM1-950, Medicine, R, DOAJ:Therapeutics, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Mashhad University of Medical Sciences
Year: 2012
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