Location of Repository

Structural Diversity of Monoclonal CD4 Antibodies and Their Capacity to Block the HIV GP120/CD4 Interaction

By Winfried Weissenhorn, Ying-Hua Chen, Christian Reiter, Christine Federle, Elisabeth H. Weiss, Gert Riethmüller and Ernst P. Rieber
Topics: Biologie, ddc:570
Year: 1996
DOI identifier: 10.1089/hyb.1996.15.117
OAI identifier: oai:epub.ub.uni-muenchen.de:14764
Provided by: Open Access LMU

Suggested articles



  1. (1990). A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site.
  2. A new method for sequencing DNA.
  3. A region in domain 1 of CD4 distinct from the primary gpl20 binding site is involved in HIV infection and virus-mediated fusion.
  4. (1990). Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.
  5. (1987). and Capon DJ: Delineation of a region of the human immunodeficiency virus type 1 gpl20 glycoprotein critical for interaction with the CD4 receptor. Cell
  6. (1992). and Schedel I: Neutralization of HIV-1 by anti-idiotypes to monoclonal anti-CD4.
  7. (1988). and Truneh A: Structural analysis of the human immunodeficiency virus binding domain of CD4.
  8. (1990). and van Regenmortel MHV: Analysis of the structural diversity of monoclonal antibodies to cyclosporine. Mol Immunol
  9. (1992). and Weidle UH: Combinatorial effect of two chimeric antibodies directed to human CD4 and of one chimeric antibody directed to the a chain of the human interleukin-2 receptor. Gene
  10. Antibody and HIV-1 gpl20 recognition of CD4 undermines the concept of mimicry between antibodies and receptors.
  11. (1990). Atomic structure of a fragment of human CD4 containing two immunoglobulin like domains. Nature (London)
  12. Binding site for human immunodeficiency virus coat protein gpl20 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.
  13. CD4+ T cells: Specificity and function.
  14. Complete variable region sequences of five homologous high affinity anti-digoxin antibodies.
  15. Complexity, polymorphism, and connectivity of mouse Vk gene families.
  16. Contributions of immunoglobulin heavy and light chains to antibody specificity for lysozyme and two haptens.
  17. (1990). Crystal structure of an HIV binding recombinant fragment of human CD4. Nature (London)
  18. (1991). Defining antibody-antigen recognition: Towards engineered antibodies and epitiopes. Int Rev Immunol
  19. (1993). EA: CD4 molecules with a diversity of mutations encompassing the CDR3 region efficiently support human immunodeficiency virus type 1 envelope glycoprotein mediated cell fusion.
  20. Fc-receptors for IgE on human lymphocytes. Detection with a rosetting assay using a recombinant human/mouse IgE antibody and characterization with monoclonal antibodies.
  21. Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.
  22. (1988). Haloperidol binding to monoclonal antibodies. Hypervariable region amino acid sequence determination.
  23. Human T lymphocytes and monocytes bear the same Leu-3(T4) antigen.
  24. (1991). Identical V region amino acid sequences and segments of sequences in antibodies of different specificities.
  25. Identification of residues in human CD4 critical for the binding of HIV.
  26. Identification of the residues in human CD4 critical for the binding of HIV.
  27. (1993). Ig CDR3-like region of the CD4 molecule is involved in HIV-induced syncytia formation but not in viral entry.
  28. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
  29. Joining of immunoglobulin heavy chain segments: Implications from a chromosome with evidence of three D-JH fusions.
  30. (1991). Many variable region genes are utilized in the antibody response of BALB/c mice to the influenza virus A/PR/8/34 hemagglutinin.
  31. Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis.
  32. Members of novel VH families are found in VDJ regions of polyclonally activated B lymphocytes.
  33. (1989). Mouse Vk gene classification by nucleic acid sequence similarity. Immunogenetics
  34. mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification.
  35. (1987). Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev
  36. Neutralisation of HIV isolates by anti-idiotypic antibodies which mimic the T4 (CD4) epitope: A potential aids vaccine.
  37. Nucleic acid sequence of an internal image bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen.
  38. Organization, structure and assembly of immunoglobulin heavy chain diversity DNA segments.
  39. (1992). Peptide sequence from the hypervariable regions of two monoclonal anti-idiotypic antibodies against the thyrotropin TSH receptor are similar to TSH and inhibit TSH increased cAMP production in FRTL-5 thyroid cells.
  40. (1995). Production of a human anti-CD4 monoclonal antibody with anti idiotypic to anti-HIV type 1 glycoprotein 120. AIDS Res Hum Retroviruses
  41. (1991). Restricted IgH chain V gene usage in the human antibody response to Haemophilus influenzae type b capsular polysaccharide.
  42. Separation of functional subsets of human T cells by a monoclonal antibody.
  43. Somatic generation of antibody diversity.
  44. (1973). Speculations on idiotypes and homobodies. Ann Immunol
  45. Structural and functional implications of a restricted antibody response to a defined antigenic region on the influenza virus hemagglutinin.
  46. Structure and expression of the human and mouse T4 genes.
  47. T lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.
  48. (1998). The 3 part of the immunoglobulin κ locus of the mouse.
  49. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.
  50. The differentiation and function of human T lymphocytes.
  51. The envelope glycoprotein of the human immunodeficiency viruses HIV-1 and HIV-2 and SIV interact with similar epitopes on their cellular receptors, the CD4 molecule.
  52. (1984). The immunoglobulin heavy chain variable region locus in the mouse, one hundred Igh-V genes comprise seven families of homologous genes.
  53. The repertoire of antibodies to a single antigenic determinant. Mol Immunol 1991;28:1387-1397. 4L Lohman
  54. (1974). Towards a network theory of the immune systems. Ann Immunol
  55. (1992). VH related idiotopes detected by site-directed mutagenesis: A study induced by the failure to find CD4 anti-idiotypic antibodies mimicking the cellular receptor of HIV.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.