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Esquistossomose mansônica: II - evolução dos níveis de proteínas séricas e do perfil eletroforético por técnicas de imunoeletroforese quantitativa Schistosomiasis mansoni: II - evolution of the levels of serum proteins and of their electrophoretic pattern as traced by quantitative immunoelectrophoresis

By Ajax Mercês Atta, Luiz Augusto Magalhães and Humberto de Araujo Rangel

Abstract

Camundongos Swiss foram infectados com 100 cercárias da linhagem mineira (BH) do Schistosoma mansoni e sacrificados semanalmente no período de 8 semanas de infecção. Os níveis de proteínas séricas totais destes animais não diferiram dos apresentados pelos animais controles. Os níveis de albumina sérica determinados por "Rocket immunoelectrophoresis" acharam-se diminuídos nas 5.&ordf;, 6.&ordf; e 7.&ordf; semanas de infecção. O perfil obtido por imunoeletroforese cruzada revelou alterações em componentes séricos com mobilidade nas regiões de gama, beta e em menor grau de alfa-globulinas, após a oviposição do parasito.<br>Swiss mice were infected with 100 cercariae of the Belo Horizonte strain of Schistosoma mansoni and were sacrificed weekly during eight weeks following of infection. The levels of serum protein totals in these animals did not differ from those presented by the control animals. However, serum albumin levels that were determined by rocket immunoelectrophoresis were lower during the 5th, 6th, and 7th weeks of infection. The pattern determined by crosed immunoelectrophoresis revealed alterations in serum components with mobility in the gamma and beta regions and, to a lesser degree, alpha-globulins, after oviposition by the parasite

Topics: Schistosoma mansoni, Camundongos, Proteínas do sangue, Schistosoma mansoni, Mice, Blood protein electrophoresis, Public aspects of medicine, RA1-1270, Medicine, R, DOAJ:Public Health, DOAJ:Health Sciences
Publisher: Universidade de São Paulo
Year: 1981
DOI identifier: 10.1590/S0034-89101981000200004
OAI identifier: oai:doaj.org/article:0037591efe1a474998e0a0eedc406ddc
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