A total of 70 five-month-old female New Zealand White rabbits were assigned in a completely randomized design, over three reproductive cycles, with two treatments: a reference diet and a half-simplified diet containing 79.83% cassava byproduct. The study evaluated body weight and feed intake of does, feed cost, number and total body weight of kits at kindling and weaning per female during three cycles, number and percentage of mortality/female/cycle, and weight gain of kits from birth to weaning. No interaction was observed between the diets and among the reproductive cycles for any evaluated characteristics. The body weight of does at the moment of weaning was similar in both groups for all three reproductive cycles. However, does fed the half-simplified diet had lower feed intake during the three reproductive cycles and, consequently, more reproductive flaws. The number of kits at weaning, body weight of kits at kindling and weaning, weight gain of kits from birth to weaning, and total body weight of kits at weaning were lower for the group of does fed the half-simplified diet and, consequently, there was a higher number and percentage of dead kits in this group. The total numbers of kits at kindling and weaning and total body weight of kits at birth during all three reproductive cycles were similar between the groups; however, total body weight of weaning rabbits was higher for the animals receiving the reference diet. It is possible to conclude that although the use of the half-simplified diet decreases the reproductive performance of does, it reduces feed cost per kg of body weight by 23.63% compared with the reference diet, proving to be a viable nutritional option for rabbit production
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