<p>Abstract</p> <p>Background</p> <p>Cervical cancer is increasing at 1.5% per year in Ireland with 50% mortality giving 2.2% of all cancer deaths. In the Mid-West region a pilot screening programme has begun to screen all women 25–60 years. 66% of Genitourinary/Sexually transmitted disease (GU/STD) clinics' abnormal smears are <25 years. Requests to abandon "opportunistic" screening prompted this GU/STD clinic audit.</p> <p>Methods</p> <p>221(8.4%) patients referred to colposcopy over 4 years were audited. Retrospective analysis was carried out on GU/STD clinic files, hospital files and computer records for biopsy reports. Ethical approval was prospectively granted.</p> <p>Results</p> <p>2637 smears were carried out from November 1999 – September 2003.</p> <p>221 patients referred to colposcopy were audited.</p> <p>1%, 3%, 5% had severe, moderate and, mild dyskaryosis, respectively, on cervical screening while 0.8%, 1.2%, 1.5% had CIN3, CIN2, CIN1 abnormalities, respectively, on biopsy with 3.5% having no abnormality (Cervical Intraepithelial Neoplasia = CIN).</p> <p>53% referred to colposcopy were <25 years.</p> <p>Conclusion</p> <p>2% had high grade lesions. 37% of high grade lesions are <25 years.</p> <p>Of the high grade lesions 13% had <it>Chlamydia trachomatis </it>(27% of CIN3) and 44% had HPV despite Relative Risks (RR) being 0.75 and 1.09 respectively. Older women had higher grade changes.</p> <p>No statistical difference was found for progression, regression and persistence in those over and under 25.</p
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