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Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit

By Martin J. O’Donnell, Maciej Pawłowski, Ziniu Zhou, Paweł Zajdel and William L. Scott


Amino acids are Nature’s combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins. We report a solid-phase synthetic route to large combinatorial variations of this fundamental scaffold, extending the variety of substituted biomimetic molecules available to successfully implement the Distributed Drug Discovery (D3) project. In a single solid-phase sequence, compatible with basic amine substituents, three-point variation is performed at the amino acid a-carbon and the amino and carboxyl functionalities

Topics: Distributed Drug Discovery (D3), fundamental peptide scaffold, biomimetics, solid-phase organic synthesis, combinatorial chemistry, Organic chemistry, QD241-441, Chemistry, QD1-999, Science, Q, DOAJ:Organic Chemistry, DOAJ:Chemistry
Publisher: MDPI AG
Year: 2010
DOI identifier: 10.3390/molecules15074961
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