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Immunodiagnosis of chronic Chagas' disease using the Tc 46 and Tc 58 antigens Imunodiagnóstico da doença de Chagas crônica utilizando os antígenos Tc 46 e Tc 58

By Valéria R.A. Pereira, Mineo Nakazawa, Veridiana C. Furtado, Frederico G.C. Abath and Yara M. Gomes


The polypeptides of 46 and 58kDa were recognized in different T. cruzi strains (Y, WSL and Colombiana) by serum of all chagasic patients studied. These polypeptides were isolated from T. cruzi Y strain and used in ELISA. The sensitivity and specificity were 97.6% [CI 95%: 86-100%] and 100% [CI 95%: 89.3-100%], respectively when Tc 46 was used. When Tc 58 was used the sensitivity and specificity were 100% [CI 95%: 89.6-100%] and 90.2% [CI 95%: 75.9-96.8%], respectively.<br>Os polipeptídeos de 46 e 58kDa foram reconhecidos em diferentes cepas de T. cruzi (Y, WSL e Colombiana) pelo soro de todos os pacientes chagásicos estudados. Estes polipeptídeos foram isolados da cepa Y e usados em ELISA. A sensibilidade e especificidade foram 97,6% [CI 95%: 86-100%] e 100% [CI 95%: 89,3-100%], respectivamente quando Tc 46 foi usada. Quando Tc 58 foi utilizada a sensibilidade e especificidade foram de 100% [CI 95%: 89,6-100%] and 90,2% [CI 95%: 75,9-96,8%], respectivamente

Topics: T. cruzi, Antígenos insolúveis, Imunodiagnóstico, Doença de Chagas, T. cruzi, Insoluble antigens, Immunodiagnosis, Chagas' disease, Medicine (General), R5-920, Medicine, R, DOAJ:Medicine (General), DOAJ:Health Sciences, Arctic medicine. Tropical medicine, RC955-962
Publisher: Sociedade Brasileira de Medicina Tropical (SBMT)
Year: 2000
DOI identifier: 10.1590/S0037-86822000000400006
OAI identifier:
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