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Effects of misoprostrol on pentylenetetrazol-induced seizures in mice Efeitos de misoprostrol sobre convulsões induzidas por pentilenotetrazol em camundongos

By Francisco das Chagas Medeiros, Maria Angelina Medeiros, Vietla Satyanarayna Rao and Eberval Gadelha Figueiredo

Abstract

The effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c, misoprostol pretreatment significantly (p<0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21 % and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions.<br>Os efeitos do misoprostrol, um análogo da prostaglandina E, sobre convulsões induzidas por pentilenotetrazol (PTZ) foram estudados em camundongos. Misoprostrol (200-800 mg/Kg) administrado por via subcutânea 45 minutos antes da dose subconvulsiva de PTZ (30 mg/Kg, i.p.) provocou crises tônico-clônicas (30 a 100%) de maneira dose-dependente e mortalidade em camundongos. Na dose de 300 g/Kg, s.c., o pré-tratamento com misoprostrol diminuiu significativamente (p<0,05) o período de latência da primeira convulsão bem como a mortalidade induzida por uma dose convulsiva de PTZ (60 mg/Kg, i.p.). Nesta dose o misoprostrol diminuiu 21 % e 36% os valores de CD50 e de LD50 do PTZ, respectivamente

Topics: convulsões, pentilenotetrazol, misoprostrol, camundongos, seizures, pentylenetetrazol, misoprostol, mice, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Internal medicine, RC31-1245, Medicine, R, DOAJ:Neurology, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Academia Brasileira de Neurologia (ABNEURO)
Year: 1997
DOI identifier: 10.1590/S0004-282X1997000500001
OAI identifier: oai:doaj.org/article:39b1ba6fb15f435eb843affaad1443ae
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