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Investigation of liver tissue and biochemical parameters of adult wistar rats treated with Arctium lappa L.

By Fabrícia Souza Predes, Sérgio Luis Pinto da Matta, Juliana Castro Monteiro and Tânia Toledo de Oliveira

Abstract

This study was carried out to evaluate the effects of Arctium lappa L. (burdock) on the liver of adult male Wistar rats as measured by light microscopy and biochemical parameters. The rats received the extract in water bottles at doses of 10 or 20 g/L daily for 40 days. There were no significant changes in the plasma levels of albumin, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transferase (GGT), total protein, total cholesterol, urea, uric acid, triacylglycerol, calcium, phosphorus, chlorine and direct bilirubin. The morphological analysis did not reveal histopathological alterations in liver tissue. Both biochemical and morphological data did not indicate A. lappa toxicity.<br>A bardana (Arctium lappa L) é uma planta trazida do Japão e aclimatada no Brasil, e é extensamente utilizada na medicina popular em todo mundo. Este estudo foi realizado para avaliar os possíveis efeitos da A. lappa no fígado e nos parâmetros bioquímicos plasmáticos em ratos Wistar adultos. Estes receberam a infusão de bardana nas doses de 10 ou 20 g de folhas secas /L de água, por 40 dias. Não houve alteração significativa nos níveis plasmáticos de albumina, aspartato transaminase (AST), alanina transaminase (ALT), gamma glutamil transferase (GGT), proteínas totais, colesterol total, uréia, ácido úrico, triglicérides, cálcio, fósforo, bilirrubina direta e cloro. A análise morfológica não revelou alterações histopatológicas no fígado. Os dados bioquímicos e morfológicos não indicaram a toxicidade da bardana

Topics: Arctium lappa, Burdock, Plasma components, Liver, Biotechnology, TP248.13-248.65, Chemical technology, TP1-1185, Technology, T, DOAJ:Biotechnology, DOAJ:Life Sciences, DOAJ:Biology and Life Sciences
Publisher: Instituto de Tecnologia do Paraná (Tecpar)
Year: 2009
DOI identifier: 10.1590/S1516-89132009000200010
OAI identifier: oai:doaj.org/article:3a203acfbcdd4008ba0da67415aec234
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