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Neurological symptoms and signs in HTLV-1 patients with overactive bladder syndrome

By Davi Tanajura Costa, André Luiz Muniz Alves dos Santos, Néviton Matos de Castro, Isadora Cristina de Siqueira, Edgar Marcelino de Carvalho Filho and Marshall Jay Glesby


OBJECTIVE: To compare neurological symptoms and signs in HTLV-1 asymptomatic carriers and HTLV-1 patients with overactive bladder (OB) syndrome. METHODS: We studied 102 HTLV-1 positive individuals without HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis) divided into two groups according to the presence or absence of OB syndrome. Clinical interview, neurological exam and proviral load was performed in all patients. RESULTS AND CONCLUSIONS: Individuals with OB were more commonly female (84.3 vs. 60.8% of asymptomatics, p=0.01). The prevalence of neurological complaints was higher in OB group, especially hand or foot numbness and arm or leg weakness. There was no difference between the groups in neurological strength and reflexes. Weakness complaint remained strongly associated with OB in multivariate logistic regression analysis adjusting for sex and age [adjusted odds ratio and 95%CI 3.59 (1.45-8.88) in arms and 6.68 (2.63-16.93) in legs]. Proviral load was also different between the two groups with higher level on OB individuals

Topics: doenças da medula espinal, bexiga urinária neurogênica, paraparesia espástica tropical, mielite, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Internal medicine, RC31-1245, Medicine, R
Publisher: Academia Brasileira de Neurologia (ABNEURO)
Year: 2012
DOI identifier: 10.1590/S0004-282X2012000400005
OAI identifier: oai:doaj.org/article:3d8ad92136964dbd97eb1f4333fa79f5
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