Location of Repository

The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting

By Luo Liqun and Tea Joy S

Abstract

<p>Abstract</p> <p>Background</p> <p>The <it>Drosophila </it>olfactory system exhibits very precise and stereotyped wiring that is specified predominantly by genetic programming. Dendrites of olfactory projection neurons (PNs) pattern the developing antennal lobe before olfactory receptor neuron axon arrival, indicating an intrinsic wiring mechanism for PN dendrites. These wiring decisions are likely determined through a transcriptional program.</p> <p>Results</p> <p>We find that loss of Brahma associated protein 55 kD (Bap55) results in a highly specific PN mistargeting phenotype. In <it>Bap55 </it>mutants, PNs that normally target to the DL1 glomerulus mistarget to the DA4l glomerulus with 100% penetrance. Loss of Bap55 also causes derepression of a GAL4 whose expression is normally restricted to a small subset of PNs. Bap55 is a member of both the Brahma (BRM) and the Tat interactive protein 60 kD (TIP60) ATP-dependent chromatin remodeling complexes. The <it>Bap55 </it>mutant phenotype is partially recapitulated by Domino and Enhancer of Polycomb mutants, members of the TIP60 complex. However, distinct phenotypes are seen in Brahma and Snf5-related 1 mutants, members of the BRM complex. The <it>Bap55 </it>mutant phenotype can be rescued by postmitotic expression of Bap55, or its human homologs BAF53a and BAF53b.</p> <p>Conclusions</p> <p>Our results suggest that Bap55 functions through the TIP60 chromatin remodeling complex to regulate dendrite wiring specificity in PNs. The specificity of the mutant phenotypes suggests a position for the TIP60 complex at the top of a regulatory hierarchy that orchestrates dendrite targeting decisions.</p

Topics: Physiology, QP1-981, Science, Q, DOAJ:Physiology, DOAJ:Biology, DOAJ:Biology and Life Sciences, Neurology. Diseases of the nervous system, RC346-429
Publisher: BioMed Central
Year: 2011
DOI identifier: 10.1186/1749-8104-6-5
OAI identifier: oai:doaj.org/article:35f47a75087c4df4bec094cc2fd18be6
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1749-8104 (external link)
  • http://www.neuraldevelopment.c... (external link)
  • https://doaj.org/article/35f47... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.