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Triple therapy with clarithromycin, amoxicillin and omeprazole for Helicobacter pylori eradication in children and adolescents

By KAWAKAMI Elisabete, OGATA Silvio Kazuo, PORTORREAL Áurea C. M., MAGNI Ana Maria, PARDO Mário Luís E. and PATRÍCIO Francy R. S.

Abstract

Background - Helicobacter pylori infection presents high prevalence in developing countries, but there are few pediatric assays evaluating antimicrobial treatment. Objective - The aim of this study was to investigate Helicobacter pylori eradication rate using a short regimen (7 and 10 days) of triple therapy with clarithromycin, amoxicillin and omeprazole. Patients and methods - Twenty-five Hp positive patients who presented severe epigastralgia, were submitted to antimicrobial treatment with amoxicillin (50 mg/kg/day - maximum dose 1g bid), clarithromycin (30 mg/kg/day - maximum dose 500 mg bid) and omeprazole (0.6 mg/kg/day - maximum dose 20 mg bid) during 7 or 10 days. After 2 months, clinical symptoms were evaluated and gastric biopsies were taken to test Hp eradication. Results - Overall eradication rate was achieved in 16/25 patients (64% - IC(95%) = 45-83%), in 11/15 (73% - IC(95%) = 51-95%) patients who used 10 days therapy course and in 5/10 (50% - IC(95%) = 19-81%) who used 7 days therapy course. Eradication drugs were well accepted and adverse effects were reported in two patients (8%). Conclusions - This triple therapy regimen had moderate efficacy (64%). The data suggests that 10 days therapy course achieves better eradication rate (73%) than 7 days course (50%) to treat Hp infection in our population

Topics: Clarithromycin, Amoxicillin, Omeprazole, Helicobacter infections, Child, Adolescence, Diseases of the digestive system. Gastroenterology, RC799-869, Specialties of internal medicine, RC581-951, Internal medicine, RC31-1245, Medicine, R, DOAJ:Gastroenterology, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
Year: 2001
OAI identifier: oai:doaj.org/article:5513637bad8740f7a6b2e159fb4cd050
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