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Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17

By Tao Liu, Jing Zhu, Song-Ya Zhang, Zhan-Lin Li, Li-Ping Guan, Hua-Qi Pan, Xin Wu, Jiao Bai and Hui-Ming Hua

Abstract

Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1- hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis

Topics: halotolerant fungus, Myrothecium sp., polyketide, furanone, Organic chemistry, QD241-441, Chemistry, QD1-999, Science, Q, DOAJ:Organic Chemistry, DOAJ:Chemistry
Publisher: MDPI AG
Year: 2013
DOI identifier: 10.3390/molecules181215126
OAI identifier: oai:doaj.org/article:3cf01fdab455473e909a6bf339e9082f
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