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Systematic approaches to mouse mutagenesis.

By S. D. Brown and Rudi Balling

Abstract

A major challenge in post-genomics is the systematic determination of mammalian gene function. A variety of mouse mutagenesis technologies, both gene- and phenotype-driven, are being used to underpin systematic and comprehensive approaches to mammalian gene function studies. Recently, a number of centres have completed large-scale ENU mutagenesis programmes that employ a phenotype-driven approach to the generation of mouse mutants. The use of ENU mutagenesis represents a powerful and efficient approach to mammalian gene-function studies, but many parallel developments are needed in downstream technologies to properly harness the new enlarged mouse-mutant resources that are being created

Topics: Animals, Ethylnitrosourea, Genetic Variation, Humans, Mice, Mice, Mutant Strains/genetics, Mutagenesis, Phenotype, Life sciences :: Genetics & genetic processes [F10], Sciences du vivant :: Génétique & processus génétiques [F10]
Year: 2001
DOI identifier: 10.1016/s0959-437x(00)00189-1
OAI identifier: oai:orbilu.uni.lu:10993/1566
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