Article thumbnail

Systematic approaches to mouse mutagenesis.

By S. D. Brown and Rudi Balling


A major challenge in post-genomics is the systematic determination of mammalian gene function. A variety of mouse mutagenesis technologies, both gene- and phenotype-driven, are being used to underpin systematic and comprehensive approaches to mammalian gene function studies. Recently, a number of centres have completed large-scale ENU mutagenesis programmes that employ a phenotype-driven approach to the generation of mouse mutants. The use of ENU mutagenesis represents a powerful and efficient approach to mammalian gene-function studies, but many parallel developments are needed in downstream technologies to properly harness the new enlarged mouse-mutant resources that are being created

Topics: Animals, Ethylnitrosourea, Genetic Variation, Humans, Mice, Mice, Mutant Strains/genetics, Mutagenesis, Phenotype, Life sciences :: Genetics & genetic processes [F10], Sciences du vivant :: Génétique & processus génétiques [F10]
Year: 2001
DOI identifier: 10.1016/s0959-437x(00)00189-1
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.