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The Multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease

By Antonina Dolei and Hervé Perron

Abstract

This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot be studied with "Mendelian genetics" concepts only. They also display complex interactions with other HERV families, and with classical viruses. These concepts may contribute to unravelling the etiopathogenesis of complex diseases such as multiple sclerosis, schizophrenia, and other chronic multifactorial diseases

Topics: MED/07 Microbiologia e microbiologia clinica
Publisher: Springer
Year: 2009
DOI identifier: 10.1080/13550280802448451
OAI identifier: oai:eprints.uniss.it:6976
Provided by: UnissResearch
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