Location of Repository

Costruzione di uno scaffold vascolarizzato per la chirurgia ortopedica

By Andrea Pellacani

Abstract

Specific aims\ud The aim is to improve the treatment of the bone losses at the metacarpal bones level (both\ud diaphysis and epiphysis) combining microsurgery, tissue engineering and biomaterials, so to\ud minimize the donor side morbidity and optimize healing and outcomes.\ud Methods\ud Pre-operative controlateral X-ray or 3-D CT to allow custom-made HA scaffolds. Cement as\ud temporary spacer in acute lesion and monitoring of infective risks. Treatment of the bone loss\ud recurring to pre-fabricated or custom-made HA scaffolds, adding platelet gel or growth factor\ud OP1. Stable synthesis. Control group with auto/omografts. Outcome indices: % of bone-union;\ud finger TAM, Kapandji, DASH score; NMR and Scintigraphy at 180 days for revascularisation\ud and bio-substitution of the scaffold.\ud Preliminary results\ud The authors just treated 6 patients, 4 males and 2 females, with an average age of 38.5 yrs,\ud affected by segmental bone losses at the hand and wrist, recurring to pre-fabricated not\ud vascularised scaffolds. In all cases the synthesis was performed with angular stability plates and\ud a stable synthesis achieved. All patients have been controlled at a mean follow-up of 10.5\ud months (from 2 to 16 ). In all case but one the bone-scaffold osteo-integration was achieved at an\ud average of 38 days at the hand, and 46 days at the wrist. The outcome studies, according to the\ud DASH score, finger TAM, and Kapandji, were good and excellent in 5 cases, poor in one

Topics: MED/33 Malattie apparato locomotore
Year: 2008
DOI identifier: 10.6092/unibo
OAI identifier: oai:amsdottorato.cib.unibo.it:704
Provided by: AMS Tesi di Dottorato

Suggested articles

Preview


To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.