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The role of inhibin-A, P-selectin and E-selectin in hypertensive disorders of pregnancy

By Γεώργιος Σαλαμαλέκης

Abstract

Aim of the study: To report plasma concentrations of the adhesion cell molecules P-selectin and E-selectin and glicoprotein inhibin-A during pregnancy and to determine the effect of subsequent development of hypertension and preeclampsia. Material and method: 81 pregnant women were enrolled in this study; 20 of them, who sudsequently developed preeclampsia, were compared with 16 who developed gestational hypertension and 45 normotensive women with normal obstetric outcome. The determination of plasma soluble P-selectin, E-selectin and inhibin-A levels was performed using a commercial sandwich immunoassay kit. We measured the inhibin-A level, the P selectin level and the E selectin level in all 81 pregnant women. The statistical analysis followed the subsequent methodology. Firstly, the women were distinguished in two groups. a) The normotensive women with normal obstetric outcome were enrolled in the 1st group (n=45) and b) all the hypertensive women in the 2nd group (n=36). Secondly, the group of hypertensive women (n=36) was divided in two subgroups: women who developed preeclampsia were enrolled in the 1st subgroup (n=20) and women who developed gestational hypertension were enrolled in the 2nd subgroup (n=16). Results: According to the findings, inhibin-A and E-selectin concentrations did not have any statistically important difference between normotensive and hypertensive pregnant women. On the contrary, there was a significant difference in P-selectin concentration between normotensive and hypertensive pregnant women (P-selectin concentration was very low in hypertensive pregnant women). In addition, in the second stage of the statistical analysis, inhibin-A and P-selectin concentrations did not have any statistically important difference between preeclamptic and gestational hypertensive women. On the contrary, there was a significant difference in E-selectin concentration between preeclamptic and gestational hypertensive women (E-selectin concentration was very low in hypertensive pregnant women). Conclusions: P-selectin may be used as a marker for hypertensive disorders of pregnancy and E-selectin as a marker for preeclampsia.

Topics: Ανασταλτίνη Α, Σελεκτίνη, Προεκλαμψία, Δυσλειτουργία ενδοθηλίου, Βιοχημικοί δείκτες, Υπερτασική νόσος εγκυμοσύνης, Inhibin A, P-selectin, E-selectin, Preeclampsia, Biochemical markers, Gestational hypertensive women
Publisher: National and Kapodistrian University of Athens
Year: 2009
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