Cardiotoxicity of Epirubicin/Paclitaxel–Containing Regimens: Role of Cardiac Risk Factors


Purpose: To evaluate the incidence of clinically rel-evant cardiac toxicity after treatment with epirubicin/ paclitaxel-containing regimens in patients with meta-static breast cancer and to identify high-risk patients in whom the benefit of chemotherapy may be negated by the occurrence of congestive heart failure (CHF). Patients and Methods: A total of 105 patients who were referred for epirubicin/paclitaxel treatment were included in this study. Treatment regimens were as follows: (1) epirubicin 90 mg/m2 plus paclitaxel 135 to 225 mg/m2 over 3 hours (n 5 76); and (2) gemcitabine 1,000 mg/m2 on days 1 and 4 plus epirubicin/pacli-taxel (n 5 29). The occurrence of CHF was detected by physical examination, and left ventricular function was evaluated by bidimensional echocardiography to sup

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