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ALKALINE PHOSPHATASE ISOENZYMES HOMOZYGOUS Β-THALASSAEMIA

By ΑΠΟΣΤΟΛΟΣ ΜΠΟΥΡΝΑΣ

Abstract

TOTAL ACTIVITY OF SERUM ALKALINE PHOSPHATASE AND ITS ISOENZYMES WAS STUDIED IN 52 PATIENTS WITH HOMOZYGOUS Β - THALASSAEMIA AND 45 NORMAL SUBJECTS. MEANS LEVEL'S OF TOTAL A.P. ACTIVITY WERE SIMILAR BETWEEN PATIENTS AND CONTROLS FOR SUBJECTS AGED 7 TO 15 YEARS WHEREAS FOR SUBJECTS AGED 16 TO 25 YEARS A.P. LEVELS WERE HIGHER IN THE PATIENTS COMPARED TO CONTROLS. THE BONE ISOENZYME WAS FOUND INCREASED A GREATER PROPORTION OF PATIENTS THAN CONTROLS FOR SUBJECTS OVER 16 YEARS OF AGE AND THIS INDICATES PESSISTRING OSTEOBLASTIC ACTIVITY IN ADOLESCENT AND ADULT PATIENTS. IN HOMOZYGOUS B - THALASSAEMIA AND IN THE NORMAL SUBJECTS THE INCREASED LEVELS OF TOTAL A.P. ACTIVITY CORRELATED WITH INCREASEDQUANTITY OF THE BONE ISOENZYME (P<0,01). NO SIGNIFICANT CHANGES OF THE HEPATIC ISOENZYME WAS OBSERVED IN HOMOZYGOUS B - THALASSAEMIA. THIS FINDING INDICATES THAT INCREASED TOTAL ACTIVITY OF A.P. IN THALASSAEMIA IS NOT ON INDEX OF HEPATIC DISFUNCTION. THE INTESTINAL A.P. WAS STUDIED IN RELATED TO ABO BLOOD GROUP PHENOTYPES AND THE SECRETOR STATUS OF THE SUBJECTS. THE DISTRIBUTION OF SECRETORS AND NON SECRETORS WAS NOT DIFFERENT BETWEEN PATIENTS AND CONTROLS. THE FREQUENCY OF THE PHENOTYPE P0 OF INTESTINAL A.P. COMPARED TO THE PHENOTYPES P+/P++ WAS HIGHER IN NORMAL SUBJECTS THAN IN THE THALASSAEMIA PATIENTS. THIS DECREASED INCIDENCE OF THE INTESTINAL (ABSTRACT TRUNCATED)

Publisher: National and Kapodistrian University of Athens
Year: 1978
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