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THE CONTRIBUTION OF THE EARLY AND LATE CASTRATION IN THE MANAGEMENT OF BREAST CANCER

By ΧΑΡΙΛΑΟΣ ΠΑΤΕΡΑΣ

Abstract

THE PRESENT CLINICAL AND STATISTICAL STUDY WAS PERFORMED IN THE 2ND DEPARTMENT OF SURGERY OF "SAINT SAVAS" HOSPITAL OF THE HELLENIC ANTICANCER INSTITUTE. THE CLINICAL MATERIAL WERE CONSISTED OF 318 FEMALE PATIENTS WITH BREAST CANCER, TREATED AT SAINT SAVAS HOSPITAL FROM JANUARY 1962 TO DECEMBER 1972. THE PATIENTS WERE DIVIDED INTO THREE MAJOR GROUPS: GROUP A: INCLUDED 147 PATIENTS WITH OPERABLE BREAST CANCER. EARLY CASTRATION WAS PERFORMED ON THEM IMMEDIATELY AFTER THE TREATMENT OF THE PRIMARY TUMOUR. GROUP B: THIS GROUP HAD 98 PATIENTS WITH INOPERABLE BREAST CANCER, MAINLY BECAUSE OF DISTANT METASTASIS. ALL CASESIN THIS GROUP UNDERWENT LATE CASTRATION. GROUP C: CONSISTED OF 73 PATIENTS WITH OPERABLE BREAST CANCER. THESE PATIENTS CONSISTED THE CONTROL GROUP AND NO CASTRATION WAS PERFORMED ON THEM, AFTER TREATMENT OF THE PRIMARY TUMOUR. THE PATIENTS OF ALL GROUPS, EXCEPT SIX PATIENTS IN GROUP B, HAD NORMAL MENSTRUAL PERIODS, DURING THEIR TREATMENT. FROM THE ANALYSIS OF THE OBTAINED RESULTS WE REACHED TO THE FOLLOWING CONCLUSIONS: 1. THERE IS NO DIFFERENCE IN MORTALITY RATE AMONG GROUPS A AND C UP TO THE 10TH YEAR OF FOLLOWING UP. HOWEVER THERE ISA DECREASE IN MORTALITY RATE IN GROUP A AS COMPARED TO GROUP C AFTER THE 10THYEAR OF FOLLOWING UP. THIS IS PERHAPS DUE TO THE FACT THAT THE PATIENTS IN GROUP A REMAIN (ABSTRACT TRUNCATED)

Publisher: National and Kapodistrian University of Athens
Year: 1976
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