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EFECT OF DIURETIC AGENTS ON RENAL ZINC EXCRETION

By ΣΠΥΡΙΔΩΝ ΝΤΟΥΡΑΚΗΣ

Abstract

THE EFFECT OF DIURETIC AGENTS ON RENAL ZINC EXCRETION WAS STUDIED BY: A) INFUSING FUROSEMIDE INTRAVENOUSLY (20 MG), ALONE OR IN COMBINATION WITH SODIUM LOADING (INFUSION OF 2 LT ISOTONIC SALINE 24 H BEFORE AND CONCOMITANT INFUSION OF 250 ML ISOTONIC SALINE DURING THE ADMINISTRATION OF FUROSEMIDE) IN 11 HEALTHY VOLUNTEERS AND B) ADMINISTRATION HYDROLLOROTHIARIDE (50 MG DAILY) ALONE OR IN COMBINATION WITH TRIAMTERENE (100 MG DAILY), PEROS FOR 5 WEEKS, IN TWO GROUPS OF A TOTAL NUMBER OF 35 PATIENTS WITH MILD ARTERIAL HYPERTENSIN (DIASTOLIC B.P< 110 MGHG). IT IS CONCLUDED THAT: 1) DIURETIC (EITHER THIARIDE OF LOOP DIURETIC) ADMINISTRATION RESULTS IN INCREASED RENAL ZINC EXCRETION. 2) THE INCREASE IN ZINC EXCRETION DURING DIURETIC ADMINISTRATION CORRESPONDS TO THE INCREASEIN SODIUM EXCRETION AND SUGGEST AN INTERELATIONSHIP BETWEEN THE MECHANISMS INVOLVED IN THE RENAL HANDLING OF THE TWO IONS. 3) CONTINUOUS URINARY ZINC LOSSES DURING CHRONIC DIURETIC TREATMENT WEIGHT RESULT IN ZINC DEPLETION WITH POTENTIAL CLINICAL IMPLICATIONS, ESPECIALLY IN OLDER INDIVIDUALS.

Topics: DIURETIC AGENTS, RENAL ZINC EXCRETION, ZINC DEPLETION, ΔΙΟΥΡΗΤΙΚΑ ΦΑΡΜΑΚΑ, ΕΝΔΕΙΑ ΨΕΥΔΑΡΓΥΡΟΥ, ΝΕΦΡΙΚΗ ΑΝΕΠΑΡΚΕΙΑ ΨΕΥΔΑΡΓΥΡΟΥ
Publisher: National and Kapodistrian University of Athens
Year: 1986
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