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PLACENTAL ENZYME POLYMORPHISMS IN NORTHERN GREECE

By ΑΝΑΣΤΑΣΙΑ ΚΟΥΒΑΤΣΗ

Abstract

THE TECHNIQUES OF SEQUENTIAL ELECTROPHORESIS AND HEAT DENATURATION WERE USED IN ORDER TO STUDY THE GENETIC VARIATION IN 11 DIFFERENT GENETIC MARKERS (APH, ACCH, G-GPD, GPGD, LDH, ESD, PGM, AK1, GPI, GOTS AND GOTM) IN PLACENTAE FROM NORTHERN GREECE. THE FETAL HAEMOGLOBINS WERE ALSO EXAMINED IS SAMPLES OF CORD BLOOD. A) A NEW APH VARIANT WAS DESCRIBED. B) THE PERCENTAGES OF G-GPD DEFICIENCY DIFFER SIGNIFICANTLY IN VARIOUS DISTRICTS. C) A NEW LDH VARIANT WAS FOUND AND PERHAPS IT REPRESENTS A NEW MUTATION. D) THE THREE LOCI (ESD, GOTS, GOTM) WERE SCREENED FOR THE FIRST TIME AMONG GREEKS. E) THE COMBINATION OF DIFFERENT METHODOLOGIES USED REVEALED MORE HETEROGENEITY ONLY AT THE PGM1 LOCUS.

Topics: BLOOD GROUPS, Cord blood, ENZYMIC VARIANTS, HEMOGLOBINS, Placenta, Polymorphisms, Population, TECHNIQUE OF SEQUENCIAL ELECTROPHORESIS, Αίμα ομφάλιου λώρου, Αιμοσφαιρίνες, Βιολογία, ΓΕΝΕΤΙΚΗ ΑΝΘΡΩΠΟΥ, ΕΝΖΥΜΙΚΕΣ ΠΑΡΑΛΛΑΓΕΣ, ΜΕΘΟΔΟΣΔΙΑΔΟΧΙΚΗΣ ΗΛΕΚΤΡΟΦΟΡΗΣΗΣ, Ομάδες αίματος, Πλακούντας, Πληθυσμός, Πολυμορφισμοί
Publisher: Aristotle University Of Thessaloniki (AUTH)
Year: 1984
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