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Characterization of 14, 15-epoxyeicosatrienoylsulfonamides as 14, 15-epoxyeicosatrienoic acid agonists: Use for studies of metabolism and ligand binding

By Wenqi Yang, Blythe B. Holmes, V. Raj Gopal, R. V. Krishna Kishore, Bhavani Sangras, Xiu-yu Yi, J. R. Falck and William B. Campbell


Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxy-genase metabolites of arachidonic acid. EETs mediate numer-ous biological functions. In coronary arteries, they regulate vascular tone by the activation of smooth muscle large-con-ductance, calcium-activated potassium (BKCa) channels to cause hyperpolarization and relaxation. We developed a serie

Year: 2007
DOI identifier: 10.1124/jpet.107.119651
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