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(Asteraceae). Biogenetic Implications and Biological Evaluation

By Hypargyrin A, Raquel Arellano-martíneza and Guillermo Delgadob

Abstract

Abstract. A new hemiacetalic germacrolide 6, named hypargyrin A, was isolated from the aerial parts of Viguiera hypargyrea, along with the known compounds (8R,9R)-β-caryophyllene epoxide, ent-kaur-16-en-19-oic acid (1), hispidulin (2), 8β-epoxyangeloyloxy-14-acetoxy-tithifolin (3), 8β-epoxyangeloyloxy-14-hydroxy-tithifolin (4) and budlein B (5). Spectroscopic analysis of 6 allowed the structural correction of a compound isolated from Blainvillea gayana. Budlein B (5) can be considered the biogenetic precursor of 6, and two path-ways for its formation are proposed. Hypargyrin A (6) did not display significant anti-inflammatory activity against ear edema in mice induced by TPA, but showed cytotoxic activity against HeLa (IC50 35.1 µM) and Hep-2 (39.2 µM) human cells

Topics: tory
Year: 2010
OAI identifier: oai:CiteSeerX.psu:10.1.1.983.7859
Provided by: CiteSeerX
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