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Comparative Studies of Multiple-Dose Cefoxitin vs. Single-Dose Cefonicid for Surgical Prophylaxis in Patients Undergoing Biliary Tract Operations or Hysterectomy

By Dennis G. Maki, Jan L. Lammers and David R. Aughey


Three hundred one patients were studied in ongoing, double-blinded, randomized clini-cal trials of the efficacy and safety of multiple-dose cefoxitin and single-dose cefonicid for the prevention of postoperative surgical infection in patients undergoing elective biliary tract operations or hysterectomy. In the biliary surgery trial, one patient (1.50/0) of 66 assessable patients given cefoxitin and three (4.7%) of 64 given cefonicid devel-oped incisional infection of the abdominal wound (P = not significant [NS]). Two (6%) of 31 patients undergoing vaginal hysterectomy who were given cefoxitin and four (14%) of 29 given cefonicid developed vaginal cuff cellulitis (P = NS); three (6%) of 49 pa-tients undergoing abdominal hysterectomy who were given cefoxitin and none of 37 given cefonicid developed pelvic cellulitis (P = NS). Adverse effects ascribable to one of the study drugs were infrequent and minor in both groups. Levelsof cefonicid in se-rum and the uterus or gallbladder wall 2-3 hr after the preoperative dose- before wound closure-were high (mean, 30-40 Ilg/ml), values five to six times higher than those for cefoxitin. The duration of postoperative hospitalization and the costs of hospi-tal care for the two treatment groups were similar in both trials. These studies sugges

Year: 2016
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