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P.: 2-Amino-3(methylamino)-propanoic acid (BMAA) in cycad flour: An unlikely cause of aniyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Neurology 40

By Mark W. Duncan, Nelly E. Villacreses, Philip G. Pearson, Lance Wyatt, Stanley I. Rapoport, Irwin J. Kopin, Sanford P. Markey and Quentin R. Smith

Abstract

2-Amino-3-(methylamino)-propanoic acid (BMAA) is a neurotoxic, excitatory amino acid which has been linked through cycad use and consumption with the onset of a variant of amyotroptiic lateral sclerosis occurring with high incidence in the western Pacific region. We have studied BMAA pharmacokinetics, oral bioavailability and blood-brain barrier permeability in the rat in an attempt to better define the possible role for BMAA in this disease. To evaluate its kinetics and uptake, BMAA (25-400 mg/kg) was administered to rats, either acutely or chronically, and then plasma and brain concentrations were determined at various times thereafter by combined gas chromatography mass spectrometry. After single dose i.v. injection, BMAA was deared from plasma in a rapid distribution phase (V 1 6 liters/kg) followed by a slower elimination phase (t1, 1 day). Brai

Topics: L-2-amino-3-(methylamino)-propanoic acid, BOAA, L-3-oxalyl-2, 3-diaminopropionic acid, CSF, cerebrospinal fluid, GC/MS, gas chromatography
Year: 1990
OAI identifier: oai:CiteSeerX.psu:10.1.1.983.5390
Provided by: CiteSeerX
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