Original Research Communications Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial1–3


Background: Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality. Objective: The intention of this study was to determine the inde-pendent and combined effects of diet-induced weight loss and ex-ercise on markers of chronic inflammation. Design: Three hundred sixteen community-dwelling, older ( 60 y), overweight or obese [body mass index (in kg/m2) 28], seden-tary men and women with radiographic evidence of knee osteoar-thritis were randomly assigned to four 18-mo treatments: healthy lifestyle control, diet-induced weight loss, exercise, and diet plus exercise. The exercise intervention consisted of combined weight training and walking for 1 h 3 times/wk. The weight-loss interven-tion consisted of a weekly session with a registered dietitian to provide education and support for lowering energy intake. Results: The diet-induced weight-loss intervention resulted in sig-nificantly greater reductions in concentrations of C-reactive protein (P 0.01), interleukin 6 (P 0.009), and soluble tumor necrosis factor receptor 1 (P 0.007) than did no weight-loss treatment. Changes in soluble tumor necrosis factor receptor 1 but not in C-reactive protein or interleukin 6 correlated with changes in body weight. Exercise training did not have a significant effect on these inflammatory biomarkers, and there was no significant interaction between weight loss and exercise training. Conclusions: These findings provide evidence from a randomized controlled trial that a dietary intervention designed to elicit weight loss reduces overall inflammation in older, obese persons. Addi-tional studies are needed to assess the effects of different modes and intensities of exercise on inflammation. Am J Clin Nutr 2004

Similar works

Full text

oai:CiteSeerX.psu: time updated on 11/2/2017

This paper was published in CiteSeerX.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.